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PostPosted: 27 May 2008, 19:36 
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Gene Mutations In Mice Mimic Human-like Sleep Disorder

ScienceDaily (May 23, 2008) — Mutations in two genes that control electrical excitability in a portion of the brain involved in sleep create a human-like insomnia disorder in mice, UT Southwestern Medical Center researchers have found. The findings may help scientists better understand the disorder and provide an animal model for developing treatments.

"This is one of the most dramatic sleep-disturbance mutations," said Dr. Rolf Joho, associate professor of neuroscience and senior author of the paper, which appears online and in the May 21 issue of The Journal of Neuroscience. "The mice sleep half as much as normal mice."

The mutant mice appeared to have a condition similar to a human disorder called sleep maintenance insomnia, in which sufferers can get to sleep, but don't remain at rest for long.

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